Author

R. Syahirah

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:zebrafish· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Q. Deng· 3 shared J. Wan· 2 shared S. Liu· 2 shared A. Hsu· 1 shared A. Y. Hsu· 1 shared C. J. Staiger· 1 shared C.-l. Chen· 1 shared G. Jin· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiophysics

Q. Deng

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Molecular basis for Gβγ-mediated activation ofphosphoinositide 3-kinase γ

C.-l. Chen, R. Syahirah, S. Ravala, Y.-C. Yen, T. Klose, Q. Deng, J. J. G. Tesmer

This study identifies two distinct Gβγ binding sites on PI3Kγ and shows how Gβγ activates the enzyme through conformational changes and allosteric control.

bioRxiv · May 4, 2023Biophysics

Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy

Y. Chang, R. Syahirah, G. Jin, X. Bao

This study engineers CAR-expressing neutrophils from human pluripotent stem cells, showing enhanced anti-tumor activity against glioblastoma in vitro and in vivo.

bioRxiv · Mar 2, 2022Bioengineering

RORA regulates neutrophil migration and activation in zebrafish

A. Y. Hsu, T. Wang, R. Syahirah, S. Liu, K. Li, W. Zhang, J. Wang, Z. Cao, S. Tian, S. Matosevic, C. J. Staiger, J. Wan, Q. Deng

This study identifies miR-99 and ROR as regulators of neutrophil migration and anti-microbial defense in zebrafish.

bioRxiv · Dec 3, 2021Cell Biology

Inducible overexpression of zebrafish microRNA-722 suppresses chemotaxis of human neutrophil like cells

A. Hsu, S. Liu, K. Brasseale, R. Syahirah, J. Wan, Q. Deng

This study shows that overexpressing zebrafish miR-722 in HL-60 cells reduces chemotaxis and inflammation-related gene expression, suggesting miR-722 suppresses neutrophil migration.

bioRxiv · Mar 14, 2019Immunology