Author

R. Torres-Ruiz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:whole-genome sequencing· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

S. Rodriguez-Perales· 2 shared A. Baez-Ortega· 1 shared A. Benitez-Burraco· 1 shared A. Curiel-Garcia· 1 shared A. Diaz-Lagares· 1 shared A. Gomez-Caturla· 1 shared A. Hernandez-Nunez· 1 shared A. L. Bruzos· 1 shared

Activity by Year

2016-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

S. Rodriguez-Perales

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Bilallelic germline mutations in MAD1L1 induce a novel syndrome of aneuploidy with high tumor susceptibility

C. Villarroya-Beltri, A. Osorio, R. Torres-Ruiz, D. Gomez-Sanchez, M. Trakala, A. Sanchez-Belmonte, F. Mercadillo, B. Pitarch, A. Hernandez-Nunez, A. Gomez-Caturla, D. Rueda, J. Perea, S. Rodriguez-Perales, M. Malumbres, M. Urioste

This study identifies biallelic MAD1L1 mutations causing aneuploidy and high tumor susceptibility, with systemic inflammation and clonal expansions observed in patient blood cells.

bioRxiv · Aug 8, 2022 · PreprintCancer Biology

Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

E. G. Alvarez, J. Demeulemeester, C. Jolly, D. Garcia-Souto, P. Otero, A. Pequeno, J. Zamora, M. Tojo, J. Temes, A. Baez-Ortega, B. Rodriguez-Martin, Y. Li, A. Oitaben, A. L. Bruzos, M. Martinez-Fernandez, , J. Tubio

The paper identifies a mutational mechanism in hepatocellular carcinoma driven by Hepatitis B virus DNA integration, leading to genomic restructuring and oncogenic rearrangements.

bioRxiv · Apr 19, 2021Cancer Biology

Somatic genome editing with the RCAS/TVA-CRISPR/Cas9 system for precision tumor modeling

B. Oldrini, A. Curiel-Garcia, C. Marques, V. Matia, O. Uluckan, R. Torres-Ruiz, S. Rodriguez-Perales, J. Huse, M. Squatrito

This paper develops a mouse model using RCAS/TVA-CRISPR/Cas9 for in vivo somatic genome editing to generate accurate cancer models.

bioRxiv · Aug 14, 2017Cancer Biology

Functional genetic characterization by CRISPR-Cas9 of two enhancers of FOXP2 in a child with speech and language impairment

R. Torres-Ruiz, A. Benitez-Burraco, M. Martínez-Lage, S. Rodríguez-Perales, P. García-Bellido

The paper uses CRISPR-Cas9 to show that two enhancers regulate FOXP2 and MDFIC in a neuroblastoma cell line, affecting their expression levels.

bioRxiv · Aug 2, 2016 · PreprintMolecular Biology