Author

R. Turk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. T. Chen· 2 shared B. Daines· 2 shared B. J. Belmont· 2 shared L. Guo· 2 shared M. D. Williams· 2 shared M. Darnell· 2 shared M. R. Stone· 2 shared M. Young· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersImmunology

A. T. Chen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Differential substrate specificity of ERK, JNK, and p38 MAP kinases toward Connexin 43

L. P. Latchford, L. S. Perez, J. E. Conage-Pough, R. Turk, M. A. Cusimano, V. I. Vargas, S. Arora, S. R. Shienvold, R. R. Kulp, H. M. Belverio, F. M. White, A. F. Thevenin

This study investigates the substrate specificity of ERK, JNK, and p38 MAP kinases toward Cx43CT, identifying distinct phosphorylation preferences and a novel ERK site.

Journal of Biological Chemistry · Mar 1, 2025Peer-reviewedBiochemistry

Switching circuits: Modulating NK cell response to TGF-β using novel receptors

R. Turk, L. Guo, B. J. Belmont, N. Bogard, A. T. Chen, M. D. Williams, M. Young, M. R. Stone, B. Daines, M. Darnell

This study identifies novel switch receptors for NK cells that enhance cytotoxicity and persistence in the presence of TGF-β through a pooled screening approach.

bioRxiv · Dec 10, 2023 · PreprintImmunology

TRAFfic signals: High-throughput CAR discovery in NK cells reveals novel TRAF-binding endodomains that drive enhanced persistence and cytotoxicity

M. D. Williams, A. T. Chen, M. R. Stone, L. Guo, B. J. Belmont, R. Turk, N. Bogard, N. Kearns, M. Young, B. Daines, M. Darnell

This study identifies TRAF-binding endodomains that enhance CAR NK cell persistence and cytotoxicity through high-throughput screening.

bioRxiv · Aug 2, 2023 · PreprintImmunology

Fast, efficient and virus-free generation of TRAC-replaced CAR T cells

J. Kath, W. Du, B. Thommandru, R. Turk, L. Amini, M. Stein, T. Zittel, S. Martini, L. Ostendorf, A. Wilhelm, L. Akyuez, A. Rehm, U. E. Hoepken, A. Pruss, A. Kuenkele, , D. L. Wagner

This paper presents a virus-free method to generate CAR T cells by inserting CARs into the TRAC locus using CRISPR-Cas and HDR, achieving up to 68% TCR-to-CAR replacement.

bioRxiv · Feb 14, 2021Immunology

CIS checkpoint deletion enhances the fitness of cord blood derived natural killer cells transduced with a chimeric antigen receptor

K. Rezvani, M. Daher, R. Basar, E. Gokdemir, N. Baran, N. Uprety, M. Mendt, L. Kerbauy, M. Hernandez Sanabria, N. Imahashi, A. Nunez, L. Li, M. Fathi, A. Rezvan, V. Mohanty, , Wei Inn

This paper combines CIS checkpoint deletion with CAR engineering in NK cells to enhance their metabolic fitness and anti-tumor activity in a lymphoma model.

bioRxiv · Mar 29, 2020 · PreprintImmunology