N. Baran

Transcriptional and phenotypic heterogeneity underpinning venetoclax resistance in AML

This study identifies four transcriptionally distinct venetoclax-resistant clusters in AML, revealing phenotypic, genetic, and drug response differences and their implications for treatment resistance.

Low concentrations of ethylene bisdithiocarbamate pesticides maneb and mancozeb impair manganese and zinc homeostasis to induce oxidative stress and caspase-dependent apoptosis in human hepatocytes

This study shows that low concentrations of maneb and mancozeb, Mn-containing fungicides, disrupt Mn and Zn homeostasis, induce oxidative stress, and cause caspase-dependent apoptosis in human hepatocytes.

Targeting DNA2 Overcomes Metabolic Reprogramming in Multiple Myeloma

This study identifies DNA2 as a key factor in mitochondrial metabolism that enables multiple myeloma cells to survive DNA damage, showing that targeting DNA2 overcomes metabolic reprogramming and enhances therapy effectiveness.

2'-O -methylation of the second transcribed nucleotide within mRNA 5' cap impacts protein production level in a cell specific manner and contributes to RNA immune evasion

This study shows that 2'-O-methylation of the second transcribed nucleotide in mRNA 5' cap affects protein production levels and contributes to RNA immune evasion in a cell-specific manner.

CIS checkpoint deletion enhances the fitness of cord blood derived natural killer cells transduced with a chimeric antigen receptor

This paper combines CIS checkpoint deletion with CAR engineering in NK cells to enhance their metabolic fitness and anti-tumor activity in a lymphoma model.