R. Veeraraghavan

Unraveling Chamber-specific Differences in Intercalated Disc Ultrastructure and Molecular Organization and Their Impact on Cardiac Conduction

This study quantifies intercalated disc structure in mouse heart chambers using advanced imaging and modeling to reveal chamber-specific differences in conduction speed.

Vascular Endothelial Barrier Protection Prevents Atrial Fibrillation by Preserving Cardiac Nanostructure

This study shows that protecting the vascular barrier by targeting Cx43 and Panx1 channels reduces atrial fibrillation episodes and preserves cardiac nanostructure.

EXTRACELLULAR PERINEXAL SEPARATION IS A PRINCIPAL DETERMINANT OF CARDIAC CONDUCTION

This study investigates the relationship between cardiac conduction velocity and extracellular space structure, finding a biphasic relationship with perinexal separation, supporting ephaptic coupling over gap junction-based conduction.

Spatial Pattern Analysis using Closest Events (SPACE): A Nearest Neighbor Point Pattern Analysis Framework for Assessing Spatial Relationships from Image Data

The paper introduces SPACE, a tool for analyzing spatial relationships in fluorescence microscopy images, showing it outperforms traditional colocalization methods.

The Cx43 Carboxyl-Terminal Mimetic Peptide alphaCT1 Protects Endothelial Barrier Function in a ZO1 Binding-Competent Manner

The study shows that the Cx43 carboxyl-terminal mimetic peptide CT1 protects endothelial barrier function by interacting with ZO1, preventing thrombin-induced breakdown.

Intercalated Disk Nanoscale Structure Regulates Cardiac Conduction

This study develops a finite element model of intercalated disk structure to show how nanoscale features influence cardiac conduction by altering electrical polarization and Na+ current activation.