B. E. Isakson

Assessing Spns2-dependent S1P Transport as a Prospective Therapeutic Target

This study evaluates a novel S1P transport blocker, SLF80821178, showing efficacy in multiple sclerosis without the cardiac side effects of SRMs, but with less lymphopenia and unchanged lymph S1P levels.

Pannexin 1 Channels Control Cardiomyocyte Metabolism and Neutrophil Recruitment During Non-Ischemic Heart Failure

This study shows that PANX1 deficiency in cardiomyocytes reduces glycolytic metabolism and protects against cardiac hypertrophy in non-ischemic heart failure by decreasing neutrophil recruitment.

Vascular Endothelial Barrier Protection Prevents Atrial Fibrillation by Preserving Cardiac Nanostructure

This study shows that protecting the vascular barrier by targeting Cx43 and Panx1 channels reduces atrial fibrillation episodes and preserves cardiac nanostructure.

Engineering Particle-based Materials for Vasculogenesis

This study investigates vasculogenesis in granular hydrogels to establish parameters for forming microvascular networks, finding that porosity enhances and RGD ligands impair network formation.

Amount of Pannexin 1 in smooth muscle cells regulates sympathetic nerve induced vasoconstriction

This study shows that varying Pannexin 1 levels in smooth muscle cells affects sympathetic nerve-induced vasoconstriction and blood pressure in mice.

Polarized localization of phosphatidylserine in endothelium regulates Kir2.1

The paper shows phosphatidylserine (PS) localizes to myoendothelial junctions (MEJs) in endothelium, inhibiting PIP2-mediated Kir2.1 activation to regulate vascular diameter.

Endothelial Pannexin 1-TRPV4 channel signaling lowers pulmonary arterial pressure

The paper shows endothelial Panx1-TRPV4 signaling via ATP and P2Y2R lowers pulmonary arterial pressure by reducing contractility.

Endothelial alpha globin is a nitrite reductase

This study shows endothelial alpha globin functions as a nitrite reductase to mediate hypoxia-induced vasodilation in resistance arteries.

Endothelial pannexin 1 channels control inflammation by regulating intracellular calcium

This study shows that endothelial pannexin 1 channels regulate inflammation by controlling intracellular calcium, which in turn affects IL-1β production and release.

Vascular Expression of Hemoglobin Alpha in Antarctic Icefish Supports Iron Limitation as Novel Evolutionary Driver

The paper shows Hb-3f is expressed in icefish vascular endothelium, supporting iron minimization as an evolutionary driver for hemoglobin loss in Antarctic Icefish.