Severe COVID-19 associated variants linked to chemokine receptor gene control in monocytes and macrophages
B. Stikker, G. Stik, R. W. Hendriks, R. Stadhouders
The paper identifies 3p21.31 as a risk locus for severe COVID-19 by linking risk SNPs to increased expression of chemokine receptors in monocytes and macrophages through CTCF-dependent regulatory elements.
bioRxiv · Jan 22, 2021Immunology