Author

M. P. J. de Winther

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2

Frequent Co-Authors

H.-J. Chen· 3 shared F. Linty· 2 shared G. Vidarsson· 2 shared J. den Dunnen· 2 shared J. Nouta· 2 shared M. Wuhrer· 2 shared W. Hoepel· 2 shared A. Lixenfeld· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersImmunology

H.-J. Chen

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Author profile →

4 papers

Recent·Most cited

ImmunologybioRxivFeb 14, 2022

The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylatedIgG1 in naive but not antigen-experienced vaccinees

J. Van Coillie, T. Pongracz, J. Rahmoeller…·Fatebenefratelli-Sacco Infectious Diseases Physic

The paper examines afucosylated IgG1 responses after BNT162b2 vaccination, finding transient responses in naive individuals that correlate with second-dose antibody levels.

DOI 10.1016/j.ebiom.2022.104408

humanproteomics

𝕏 PostBluesky

ImmunologybioRxivJul 13, 2020

Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses

W. Hoepel, H.-J. Chen, S. Allahverdiyeva…·J. den Dunnen

Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients induces hyper-inflammatory responses in macrophages, leading to endothelial barrier breakdown and microvascular thrombosis.

DOI 10.1126/scitranslmed.abf8654

humanproteomics

𝕏 PostBluesky

ImmunologybioRxivMay 13, 2020

SIRPalpha on mouse B1 cells restricts lymphoid tissue migration and natural antibody production

T. van den Berg, K. Franke, S. Y. Pillai…·M. P. J. de Winther

This study shows SIRPalpha on mouse B1 cells limits migration and natural antibody production, suggesting it as a therapeutic target for atherosclerosis.

DOI 10.3389/fimmu.2020.570963

mouseproteomics

𝕏 PostBluesky

ImmunologybioRxivJan 29, 2019

Defining tissue- and disease-associated macrophages using a transcriptome-based classification model

H.-J. Chen, A. Y. F. Li Yim, G. R. Griffith…·M. P. J. de Winther

This paper develops a classifier, macIDR, to identify macrophage subtypes from transcriptomic data and applies it to define tissue- and disease-specific macrophage characteristics.

DOI 10.3389/fimmu.2019.02887

humanbulk RNA-seq

𝕏 PostBluesky