VLK drives extracellular phosphorylation of EphB2 to govern the EphB2-NMDAR interaction and injury-induced pain
Kolluru D. Srikanth, Hajira Elahi, Praveen Chander, Halley R. Washburn, Shayne N. Hassler, Juliet M. Mwirigi, Moeno Kume, Jessica Loucks, Rohita Arjarapu, Rachel Hodge, Stephanie I. Shiers, Ishwarya Sankaranarayanan, Hediye Erdjument‐Bromage, Thomas A. Neubert, Zachary T. Campbell, , Matthew B. Dalva
This study identifies VLK as an extracellular kinase that mediates EphB2 phosphorylation and pain responses by regulating synaptic protein interactions.
bioRxiv · Mar 18, 2024 · PreprintNeuroscience