Moeno Kume

Persistent changes in nociceptor translatomes govern hyperalgesic priming in mouse models

The paper identifies persistent changes in nociceptor mRNA translation following hyperalgesic priming and shows Gpr88 and Metrn regulate this state.

VLK drives extracellular phosphorylation of EphB2 to govern the EphB2-NMDAR interaction and injury-induced pain

This study identifies VLK as an extracellular kinase that mediates EphB2 phosphorylation and pain responses by regulating synaptic protein interactions.

Protease-Activated Receptor 2 (PAR2) expressed in sensory neurons contributes to signs of pain and neuropathy in paclitaxel treated mice

This study shows that PAR2 in sensory neurons contributes to paclitaxel-induced pain and neuropathy in mice, and that targeting PAR2 can alleviate these symptoms.

Meteorin alleviates Paclitaxel-induced peripheral neuropathy in mice

This paper shows that recombinant mouse Meteorin reduces paclitaxel-induced neuropathy in mice by reversing glial reactivity and preventing nerve fiber loss.

A female-specific role for Calcitonin Gene-Related Peptide (CGRP) in rodent pain models

This study investigates the sex-specific role of CGRP in pain models, finding that CGRP promotes pain plasticity in female mice but has limited impact in males.

A role for protease activated receptor type 3 (PAR3) in nociception demonstrated through development of a novel peptide agonist

The paper develops a PAR3 agonist and shows it induces mechanical hypersensitivity in mice, suggesting PAR3's role in nociception and plasticity.

The cellular basis of protease activated receptor type 2 (PAR2) evoked mechanical and affective pain

This study identifies a specific subset of sensory neurons expressing PAR2 that mediate mechanical and affective pain behaviors, clarifying the cellular basis of PAR2-evoked pain.