MASH-in-a-dish reveals fatty acid-driven itaconate crosstalk between Kupffer cells and hepatocytes
Jung-Chin Chang, Annika Sullock Enzlin, Maya W. Haaker, Ennis Maiguashca Sorensen, Tessa van der Leek, Bianca Mascarenhas, Thomas Alexander Kluiver, Saskia van Essen, Laura Bongiovanni, Rachel Thomas, Weng Chuan Peng, Coen Paulusma, Esther A. Zaal, Bart Westendorp, Alain de Bruin, , Celia R. Berkers
The paper develops an in vitro MASH model to study metabolite crosstalk between Kupffer cells and hepatocytes, identifying itaconate as a key mediator of liver disease progression.
bioRxiv · Nov 2, 2026 · PreprintBiochemistry