Characterization and Preclinical Treatment of Rotational Force-Induced Brain Injury
Alan Umfress, Ayanabha Chakraborti, Suma Priya Sudarsana Devi, Raegan Adams, Daniel Epstein, Adriana V. F. Massicano, Anna G. Sorace, Sarbjit Singh, M. Iqbal Hossian, Shaida A. Andrabi, David K. Crossman, Nilesh Kumar, M. Shahid Mukhtar, Claire M. Simpson, Kathryn Abell, , James A. Bibb
This study develops a rodent model of rotational head trauma, identifies Cdk5 as a key mediator, and shows its inhibition reduces cognitive and pathological effects.
bioRxiv · Jul 20, 2022 · PreprintNeuroscience