A developmental program of early residency promotes the differentiation of divergent uterine NK cell subsets in humans
Morgan E. Greene, Rebecca Asiimwe, Emma D. Wright, Markayla Bell, Daniel Epstein, Brittney Knott, Samantha Fry, Stephanie Clevenger, Holly Elizabeth Richter, Aharon G. Freud, Shawn C. Little, Paige M. Porrett
This study identifies a developmental program in human uterine NK cells that links tissue residency with divergent effector functions through TGF-β responsive gene regulation.
bioRxiv · Jul 5, 2025 · PreprintImmunology