Metabolic and age-associated epigenetic barriers during direct reprogramming of mouse fibroblasts into induced cardiomyocytes
Francisco dos Santos, Magda Correia, Rafaela Dias, Bárbara Bola, Roberta Noberini, Rita S. Ferreira, Diogo Trigo, Pedro M. Domingues, José Teixeira, Tiziana Bonaldi, Paulo Jorge Oliveira, Christian Bär, Bruno Bernardes de Jesus, Sandrina Nóbrega Pereira
This study identifies metabolic and age-related epigenetic barriers in converting mouse fibroblasts to induced cardiomyocytes, showing that metabolic modulation enhances reprogramming efficiency.
Aging Cell · Nov 14, 2024Peer-reviewedCell Biology