Christian Bär

This study examines natural cardiovascular aging in non-human primates, finding histological and molecular changes associated with aging, including fibrosis, inflammation, and atherosclerosis.

This study shows that modGLA mRNA therapy reverses Fabry disease phenotypes in human iPSC-derived cardiomyocytes by restoring enzyme activity and normalizing molecular alterations.

This study demonstrates that modRNA hTERT treatment reduces fibrosis markers and senescence in human lung cells and tissue slices.

This study identifies metabolic and age-related epigenetic barriers in converting mouse fibroblasts to induced cardiomyocytes, showing that metabolic modulation enhances reprogramming efficiency.