Paulo Jorge Oliveira

Micronuclear collapse under oxidative stress drives amphisome-mediated export of DNA in Parkinson disease

The paper shows that oxidative stress causes micronuclear collapse in Parkinson's fibroblasts, leading to DNA export via amphisomes and pro-inflammatory EVs, which can be mitigated by a mitochondria-targeted antioxidant.

TRIB2 supports a high glycolytic phenotype in melanoma cells

This study shows TRIB2 promotes glycolysis in melanoma cells, contributing to therapy resistance and suggesting it as a potential therapeutic target.

Adenine nucleotide translocase 2 silencing promotes metabolic adaptations and anoikis in P19 embryonal carcinoma stem cells

This study shows that silencing ANT2 in P19 embryonal carcinoma stem cells reduces cell growth, promotes metabolic shifts, and increases anoikis sensitivity.

Extracellular matrix mechanical cues (dys)regulate metabolic redox homeostasis due to impaired autophagic flux

This study shows that soft extracellular matrix reduces autophagic flux and disrupts redox balance in neuronal cells, mimicking neurodegenerative disease features.

Metabolic and age-associated epigenetic barriers during direct reprogramming of mouse fibroblasts into induced cardiomyocytes

This study identifies metabolic and age-related epigenetic barriers in converting mouse fibroblasts to induced cardiomyocytes, showing that metabolic modulation enhances reprogramming efficiency.

Cardiac Molecular Analysis Reveals Aging-Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation Via Hexosamine Biosynthetic Pathway

This study identifies age-related metabolic shifts in baboon hearts that promote glycosaminoglycan accumulation via the hexosamine biosynthetic pathway, preceding cardiac hypertrophy.

Quantitative analysis of neuronal mitochondrial movement reveals patterns resulting from neurotoxicity of rotenone and 6-hydroxydopamine

The paper develops a computational method to analyze mitochondrial movement in neurons and shows it detects early neurotoxicity effects from rotenone and 6-hydroxydopamine.