Partially differentiated enterocytes in ileal and distal-colonic human F508del-CF-enteroids 1 secrete fluid in response to forskolin and linaclotide.
Rong Yan, Zixin Zhang, Hugo R. de Jonge, Ruxian Lin, Huimin Yu, Rafiq Sarker, Dario Boffelli, Rachel K. Zwick, Ophir D. Klein, Chung‐Ming Tse, Mark Donowitz, Varsha Singh
The paper shows partially differentiated CFTR-mutant enteroids secrete fluid in response to forskolin and linaclotide, with reduced efficacy compared to healthy enteroids.
iScience · Apr 17, 2025Peer-reviewedPhysiology