Sphingosine-1-phosphate regulates Plasmodium histone deacetylase activity and exhibits epigenetic control over cell death and differentiation
Raj Kumar Sah, Sakshi Anand, Geeta Kumari, Monika Saini, Rahul Singh Hada, Evanka Madan, Aashima Gupta, Shailja Singh
This study shows that S1P from host erythrocytes regulates PfHDAC-1 activity, affecting transcription of genes related to gametocytogenesis, virulence, and proliferation in Plasmodium falciparum.
bioRxiv · Jun 9, 2022 · PreprintMolecular Biology