Enhancing adeno-associated virus cellular entry through receptor engineering
Bijay P. Dhungel, Rajini Nagarajah, Cynthia Metierre, Feng Yue, Victoria Kaiser, Harrison Bazley, Catherine Curry, Divya Gokal, Alex Sherman, Qian Peter Peter Su, Mehdi Sharifi Tabar, John E.J. Rasko, Charles G. Bailey
This study investigates the molecular mechanisms of AAV receptor AAVR and AAVR2, identifies functional motifs, and demonstrates enhanced AAV entry through engineered receptors.
bioRxiv · May 26, 2026 · PreprintMolecular Biology