John E.J. Rasko

This study identifies ZNF185B as a novel isoform of ZNF185 that is upregulated in CTCF-depleted endometrial cancer cells and promotes cancer cell proliferation.

This study investigates the molecular mechanisms of AAV receptor AAVR and AAVR2, identifies functional motifs, and demonstrates enhanced AAV entry through engineered receptors.

This study identifies ZNF512B as a neuronal-expressed protein that interacts with the NuRD complex to regulate neural-specific gene expression programs.

The paper identifies unique protein interaction networks in CHD family remodelers by analyzing intrinsically disordered regions and aggregation-prone regions, revealing their role in transcriptional regulation.

The paper investigates how RNA modifications m6A and 5hmC regulate gene expression in monocytes and macrophages during differentiation and polarization, finding their roles in transcript stability and function.

The paper shows that chromatin accessibility influences cell-type specific intron retention and confirms intrinsic intron features affect splicing.

SpliceWiz provides an efficient and accurate tool for analyzing alternative splicing in RNA sequencing data, with enhanced visualization and filtering capabilities.

The paper shows that chronic myeloid leukemia patients in molecular remission still have widespread aberrant alternative splicing, unlike normal gene expression and DNA methylation patterns.

This study investigates the impact of Ctcf haploinsufficiency on alternative splicing across multiple tissues, finding tissue-specific increases in intron retention, particularly in genes related to cytoskeletal organization, splicing, and metabolism.

This study uses single-cell RNA sequencing on multi-sector glioma biopsies to analyze tumor heterogeneity, revealing spatial patterns of invasion, progression branches, and cell-cell communication.