Justin J. -L. Wong

DiffMethylTools improves detection, annotation, and visualization of differential DNA methylation, outperforming existing tools on long-read methylomes.

This paper maps mutation-defined cancer vulnerabilities across 22 cohorts, identifying OXPHOS addiction in CDKN2A-loss LUSC and highlighting drug repurposing opportunities using a machine learning framework.

The paper investigates how RNA modifications m6A and 5hmC regulate gene expression in monocytes and macrophages during differentiation and polarization, finding their roles in transcript stability and function.

The paper shows that chromatin accessibility influences cell-type specific intron retention and confirms intrinsic intron features affect splicing.

SpliceWiz provides an efficient and accurate tool for analyzing alternative splicing in RNA sequencing data, with enhanced visualization and filtering capabilities.

The paper shows that chronic myeloid leukemia patients in molecular remission still have widespread aberrant alternative splicing, unlike normal gene expression and DNA methylation patterns.

This study investigates the impact of Ctcf haploinsufficiency on alternative splicing across multiple tissues, finding tissue-specific increases in intron retention, particularly in genes related to cytoskeletal organization, splicing, and metabolism.