Ulf Schmitz

This study benchmarks fusion detection methods using long-read RNA sequencing, finding that ONT PCR-cDNA with CTAT-LR-Fusion offers the best balance of precision and recall.

This paper validates the TARGET-SL framework for predicting genetic events and drug sensitivities in liver cancer using cell lines and patient-derived organoids, showing potential to improve personalized drug screening.

ICON improves cell type classification in scRNA-seq by incorporating isoform-level data, achieving better resolution than gene-level methods.

ScIsoX provides a framework to measure isoform-level transcriptomic complexity in single cells, revealing multidimensional patterns missed by gene-level approaches.

This study identifies ZNF512B as a neuronal-expressed protein that interacts with the NuRD complex to regulate neural-specific gene expression programs.

The paper shows that chromatin accessibility influences cell-type specific intron retention and confirms intrinsic intron features affect splicing.

SpliceWiz provides an efficient and accurate tool for analyzing alternative splicing in RNA sequencing data, with enhanced visualization and filtering capabilities.

The paper shows that chronic myeloid leukemia patients in molecular remission still have widespread aberrant alternative splicing, unlike normal gene expression and DNA methylation patterns.

This study investigates the impact of Ctcf haploinsufficiency on alternative splicing across multiple tissues, finding tissue-specific increases in intron retention, particularly in genes related to cytoskeletal organization, splicing, and metabolism.