Jeremy E. Purvis

Sex differences in senescence burden within human osteoarthritic synovial fibroblasts

This study finds that female OA synovial fibroblasts show higher senescence markers and reduced oxidative stress response compared to males.

Non-Genetic Mechanisms of Fractional Resistance to Abemaciclib in Dedifferentiated Liposarcoma.

The paper identifies non-genetic resistance mechanisms in dedifferentiated liposarcoma to abemaciclib by analyzing cell-cycle regulators in cell lines and patient samples.

Extrachromosomal DNA Gives Cancer a New Evolutionary Pathway

The paper shows that ecDNA allows tumors to adapt rapidly by maintaining a spectrum of gene expression levels across cells, rather than relying on clonal expansion.

Multiplexed single-cell imaging reveals diverging subpopulations with distinct senescence phenotypes during long-term senescence induction.

The paper uses single-cell proteomics to identify two distinct senescence subpopulations with different SASP characteristics during long-term stress.

TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress

This study identifies TRIP13 as a key factor protecting KRAS-mutant pancreatic cancer cells from DNA replication stress and therapy-induced damage.

Cellograph: A Semi-supervised Approach to Analyzing Multi-condition Single-cell RNA-sequencing Data Using Graph Neural Networks

Cellograph uses graph neural networks to analyze multi-condition single-cell RNA-seq data, quantifying perturbation effects at single-cell resolution and outperforming existing methods.

Feature selection for preserving biological trajectories in single-cell data

This paper introduces DELVE, a feature selection method that improves trajectory inference by identifying dynamically expressed features that better represent biological processes in single-cell data.

Single-cell dynamics of core pluripotency factors in human pluripotent stem cells

This study uses CRISPR/Cas9 and microraft arrays to track OCT4, SOX2, and NANOG dynamics in human stem cells during differentiation, revealing spatiotemporal patterns in germ layer formation.

Integrating temporal single-cell gene expression modalities for trajectory inference and disease prediction

This study benchmarks integration methods for temporal single-cell gene expression data to improve trajectory inference and disease prediction.

The Consequences of Differential Origin Licensing Dynamics in Distinct Chromatin Environments

The paper quantifies MCM loading dynamics in euchromatin and heterochromatin during G1 phase, revealing differential rates and consequences for genome stability.

Inferring the structures of signaling motifs from paired dynamic traces of single cells

The paper develops an algorithm to infer signaling motifs from single-cell time-series data and demonstrates its application to yeast stress response.

Evidence that the cell cycle is a series of uncoupled, memoryless phases

The paper quantifies cell cycle phase durations in human cells and finds they are memoryless and uncoupled, with a mathematical model explaining their independence and potential coupling under dysfunction.

Inheritance of OCT4 predetermines fate choice in human embryonic stem cells

The paper shows that OCT4 inheritance predetermines fate choice in human embryonic stem cells, with higher OCT4 ratios in daughters leading to sustained pluripotency and reduced differentiation potential.

The Cell Cycle Browser: an interactive tool for visualizing, simulating, and perturbing cell cycle progression

The Cell Cycle Browser allows users to visualize, simulate, and perturb cell cycle progression using real-time reporter data from human cells.

DNA Damage Checkpoint Dynamics Drive Cell Cycle Phase Transitions

This study examines how DNA damage checkpoints affect cell cycle phase transitions, revealing phase-specific differences in checkpoint sensitivity and cell fate outcomes.