Author

Margaret A. Redick

Oregon State UniversityORCID 0000-0002-1901-458XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Adriana S. BeltrániD· 2 shared Jeremy E. PurvisiD· 2 shared Katarzyna M. KedzioraiD· 2 shared Samuel C. WolffiD· 2 shared Tarek M. ZikryiD· 2 shared Cierra D. DungeeiD· 1 shared Guang Ken Lin· 1 shared Jeremy M. SimoniD· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersDevelopmental Biology

Adriana S. BeltránORCID

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2 papers

Recent·Most cited

Single-cell dynamics of core pluripotency factors in human pluripotent stem cells

Sonja Mihailovic, Samuel C. Wolff, Katarzyna M. Kedziora, Nicole M. Smiddy, Margaret A. Redick, Yuli Wang, Guang Ken Lin, Tarek M. Zikry, Jeremy M. Simon, Travis Ptacek, Nancy L. Allbritton, Adriana S. Beltrán, Jeremy E. Purvis

This study uses CRISPR/Cas9 and microraft arrays to track OCT4, SOX2, and NANOG dynamics in human stem cells during differentiation, revealing spatiotemporal patterns in germ layer formation.

bioRxiv · Dec 13, 2022 · PreprintDevelopmental Biology

Inheritance of OCT4 predetermines fate choice in human embryonic stem cells

Samuel C. Wolff, Katarzyna M. Kedziora, Raluca Dumitru, Cierra D. Dungee, Tarek M. Zikry, Adriana S. Beltrán, Rachel A. Haggerty, JrGang Cheng, Margaret A. Redick, Jeremy E. Purvis

The paper shows that OCT4 inheritance predetermines fate choice in human embryonic stem cells, with higher OCT4 ratios in daughters leading to sustained pluripotency and reduced differentiation potential.

Molecular Systems Biology · Sep 1, 2018Peer-reviewedSystems Biology