Sphingosine 1-phosphate receptor-1 signaling enhances neutrophil survival while suppressing inflammation and bacterial host defense functions
Yueh‐Chien Lin, Takahiro Seno, Alan Yi-Hui Hsu, Andréane Cartier, Andrew Kuo, Michel V. Levesque, Avishek Ghosh, Ingo Fohmann, Victoria A. Blaho, Sylvain Galvani, Reed Crocker, Samuel W. Kazer, José Ordovás-Montañés, Hongbo Robert Luo, Timothy Hla
This study shows that S1PR1 signaling in neutrophils enhances their survival and reduces inflammation but impairs bacterial clearance and protects against lung injury in viral infections.
bioRxiv · Aug 28, 2026 · PreprintImmunology