Author

Andrew Kuo

Boston Children's HospitalORCID 0000-0002-7263-8658Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Timothy HlaiD· 3 shared Masanori AikawaiD· 2 shared Michel V. LevesqueiD· 2 shared Richard L. ProiaiD· 2 shared Sasha A. SinghiD· 2 shared Alan Yi-Hui HsuiD· 1 shared Andréane CartieriD· 1 shared Anja NitzscheiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersImmunology

Timothy HlaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Sphingosine 1-phosphate receptor-1 signaling enhances neutrophil survival while suppressing inflammation and bacterial host defense functions

Yueh‐Chien Lin, Takahiro Seno, Alan Yi-Hui Hsu, Andréane Cartier, Andrew Kuo, Michel V. Levesque, Avishek Ghosh, Ingo Fohmann, Victoria A. Blaho, Sylvain Galvani, Reed Crocker, Samuel W. Kazer, José Ordovás-Montañés, Hongbo Robert Luo, Timothy Hla

This study shows that S1PR1 signaling in neutrophils enhances their survival and reduces inflammation but impairs bacterial clearance and protects against lung injury in viral infections.

bioRxiv · Aug 28, 2026 · PreprintImmunology

Endothelial-derived sphingolipids are required for vascular development and systemic lipid homeostasis

Andrew Kuo, Antonio Checa, Colin Niaudet, Bongnam Jung, Zhongjie Fu, Craig Edward Wheelock, Sasha A. Singh, Masanori Aikawa, Lois E. H. Smith, Richard L. Proia, Timothy Hla

This study shows that endothelial-derived sphingolipids are essential for vascular development and systemic lipid homeostasis, with effects on retinal vascularization and liver toxicity.

eLife · Oct 5, 2022Peer-reviewedDevelopmental Biology

Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta

Eric Engelbrecht, Michel V. Levesque, Liqun He, Michael Vanlandewijck, Anja Nitzsche, Hira Niazi, Andrew Kuo, Sasha A. Singh, Masanori Aikawa, Kristina M. Holton, Richard L. Proia, Mari Kono, William T. Pu, Eric Camerer, Christer Betsholtz, Timothy Hla

The paper characterizes S1PR1-regulated transcriptomes in aortic endothelial cells, revealing distinct subtypes and signaling mechanisms in arterial and lymphatic endothelium.

eLife · Feb 24, 2020Peer-reviewedMolecular Biology