Sphingosine 1-phosphate receptor-1 signaling enhances neutrophil survival while suppressing inflammation and bacterial host defense functions
Yueh‐Chien Lin, Takahiro Seno, Alan Yi-Hui Hsu…·Timothy Hla
This study shows that S1PR1 signaling in neutrophils enhances their survival and reduces inflammation but impairs bacterial clearance and protects against lung injury in viral infections.