Renshu Zhang

Axonal dysfunction precedes axonal degeneration in a mouse model of progressive parkinsonism

The paper investigates early axonal dysfunction in a mouse model of Parkinson's disease, finding reduced calcium signals and impaired action potential propagation before axonal degeneration.

Dendrite-specific synaptic inputs onto dopaminergic SNc neurons

The paper identifies dendrite-specific synaptic inputs onto dopaminergic SNc neurons from STN, PPN, and SNr, revealing distinct functional roles of these inputs.

High-frequency axonal bursts mediate bidirectional modulation of dopamine signaling by nicotinic receptors

This study shows that nicotinic receptors modulate dopamine signaling by both enhancing and suppressing axonal activity through bidirectional mechanisms.

Presynaptic GABAA receptors control integration of nicotinic input onto dopaminergic axons in the striatum

The paper investigates how GABAARs on dopaminergic axons modulate nicotinic input integration, showing that GABAAR antagonism enhances nAChR-evoked activity.

Corticonigral projections recruit substantia nigra pars lateralis dopaminergic neurons for auditory threat memories

The paper identifies robust corticonigral projections to substantia nigra pars lateralis dopaminergic neurons involved in auditory threat memory, contrasting with sparse cortical input to other nigral populations.

Fast-synaptic axo-axonal transmission from striatal cholinergic interneurons onto dopamine fibers.

The paper demonstrates fast synaptic-like transmission from striatal cholinergic interneurons to dopaminergic axons, showing axonal integration of synaptic input into spiking.

Axonal mechanisms mediating GABA-A receptor inhibition of striatal dopamine release

The paper investigates how GABA-A receptors on dopaminergic neuron axons modulate striatal dopamine release and shows that diazepam enhances this inhibition.

Functional dissection of basal ganglia inhibitory input onto SNc dopaminergic neurons

The paper identifies inhibitory inputs to SNc dopaminergic neurons and shows that striosomal inputs can produce pause-rebound firing independently of excitatory input.