Author

Alex C. Cummins

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:non-human primate· 4 Research Focus:cell type annotation· 3 Assay:electronic health records· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:spatial domain detection· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Bruno B. AverbeckiD· 5 shared Mark A. G. EldridgeiD· 5 shared Anya S. PlotnikovaiD· 4 shared Arya Mohanty· 4 shared Brenda Leyva GarciaiD· 4 shared Chris J. McBainiD· 4 shared Elisabetta FurlanisiD· 4 shared Geoffrey A. VargishiD· 4 shared

Activity by Year

2022-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersNeuroscience

Bruno B. AverbeckORCID

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Author profile →

5 papers

Recent·Most cited

Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution.

June Hoan Kim, Anna Vlachos, Vivek Mahadevan, Adam Caccavano, Tue G. Banke, Oliver Crawley, Ana I. Navarro, Xiaoqing Q Yuan, Daniel T. Abebe, Steven Hunt, Geoffrey A. Vargish, Ramesh Chittajallu, Mark A. G. Eldridge, Reza Azadi, Alex C. Cummins, , Kenneth A. Pelkey

The paper shows that eGlyRs in hippocampal interneurons regulate network activity through developmental and evolutionary conserved mechanisms.

bioRxiv · Sep 24, 2025 · PreprintNeuroscience

A novel, evolutionarily conserved inhibitory circuit selectively regulates dentate gyrus mossy cell function.

Geoffrey A. Vargish, Haley Rice, Xiaoqing Q Yuan, Steven Hunt, Brendan E. Hines, Anya S. Plotnikova, Arya Mohanty, Elisabetta Furlanis, Yating Wang, Min Dai, Brenda Leyva Garcia, Alex C. Cummins, Mark A. G. Eldridge, Bruno B. Averbeck, Kareem A. Zaghloul, , Chris J. McBain

The paper identifies a novel inhibitory interneuron subtype in the dentate gyrus that selectively regulates mossy cell function and shows this pattern is evolutionarily conserved across species.

bioRxiv · Jul 9, 2025 · PreprintNeuroscience

An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes

Elisabetta Furlanis, Min Dai, Brenda Leyva Garcia, Thien Khai Tran, Josselyn Vergara, Ana Pereira, Bram L. Gorissen, Sara Wills, Anna Vlachos, Ariel Hairston, Deepanjali Dwivedi, Sarah Du, Justin McMahon, Shuhan Huang, Annunziato Morabito, , Yating Wang

The paper identifies enhancer-AAV tools for specific neuronal subtypes and validates them across species.

Neuron · May 1, 2025Peer-reviewedNeuroscience

Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development

Adam Caccavano, Anna Vlachos, Nadiya McLean, Sarah Kimmel, June Hoan Kim, Geoffrey A. Vargish, Vivek Mahadevan, Lauren T. Hewitt, Anthony M. Rossi, Ilona Spineux, Sherry Jingjing Wu, Elisabetta Furlanis, Min Dai, Brenda Leyva Garcia, Yating Wang, , Chris J. McBain

The paper shows that opioids suppress inhibition in hippocampal PV-INs but not neocortex across species and development, highlighting conserved and divergent roles in neural circuits.

bioRxiv · Jan 20, 2024Neuroscience

Fast-synaptic axo-axonal transmission from striatal cholinergic interneurons onto dopamine fibers.

Paul F. Kramer, Samuel G. Brill-Weil, Alex C. Cummins, Renshu Zhang, Gisela Andrea Camacho‐Hernandez, Amy Hauck Newman, Mark A. G. Eldridge, Bruno B. Averbeck, Zayd M. Khaliq

The paper demonstrates fast synaptic-like transmission from striatal cholinergic interneurons to dopaminergic axons, showing axonal integration of synaptic input into spiking.

Neuron · Aug 4, 2022Peer-reviewedNeuroscience