Emily L Twedell

The paper identifies robust corticonigral projections to substantia nigra pars lateralis dopaminergic neurons involved in auditory threat memory, contrasting with sparse cortical input to other nigral populations.

This study investigates how striatal lateral inhibition affects action selection in a mouse model of levodopa-induced dyskinesia, finding that altered inhibition contributes to involuntary movements.

The paper investigates how levodopa-induced dyskinesia is linked to increased activity in specific striatal direct pathway medium spiny neurons, driven by dopamine and excitatory inputs.

This study uses calcium imaging and optical DBS in parkinsonian mice to show that STN DBS disrupts STN activity dynamics, not inhibition or antidromic activation, to relieve motor symptoms.

The paper investigates how GABA-A receptors on dopaminergic neuron axons modulate striatal dopamine release and shows that diazepam enhances this inhibition.

The paper identifies inhibitory inputs to SNc dopaminergic neurons and shows that striosomal inputs can produce pause-rebound firing independently of excitatory input.