Castration delays epigenetic aging and feminises DNA methylation at androgen-regulated loci
Victoria J Sugrue, Joseph Alan Zoller, Pritika J. Narayan, Ake Tzu-Hui Lu, Oscar Ortega‐Recalde, Matthew J. Grant, Christopher Simon Bawden, Skye R. Rudiger, Amin Haghani, Donna M. Bond, Reuben R Hore, Michael Garratt, Karen E. Sears, Nan Wang, X. William Yang, , Steve Horvath
This study develops an epigenetic clock for sheep and finds that castration slows aging and feminizes DNA methylation at androgen-regulated loci.
eLife · Jun 28, 2021Peer-reviewedDevelopmental Biology