Joseph Alan Zoller

This study develops epigenetic clocks for axolotls, revealing biphasic age prediction during early life but not later, and highlights methylome stability across lifespan.

The paper introduces an R package for constructing and evaluating DNA methylation-based epigenetic clocks in mammals.

This study shows that young porcine plasma treatment reduces epigenetic age in multiple rat organs and improves physiological function.

The paper develops universal epigenetic clocks that accurately estimate age across mammalian tissues using DNA methylation data from 185 species.

This study shows that young rat plasma reduces DNA methylation age, extends lifespan, and improves health in old rats.

The paper compares morphological and DNA methylation differences between island and mainland masked shrews, finding epigenetic and phenotypic divergence.

This paper develops an epigenetic clock for humpback whales using DNA methylation data, showing high accuracy for known ages but underestimation in older individuals and applicability to beluga whales.

The paper develops DNA methylation clocks for clawed frogs, showing evolutionary conservation of epigenetic ageing mechanisms between frogs and mammals.

The paper identifies gastrulation in Xenopus laevis as the stage with the lowest epigenetic age and highest developmental disruption, suggesting it as the onset of aging.

The paper examines epigenetic age acceleration (EAA) across multiple tissues in HIV-infected individuals, finding tissue-specific correlations and associations with clinical conditions and sex.

This paper develops epigenetic clocks for horses using DNA methylation data from multiple tissues, showing age-related CpGs are near developmental genes and that castration does not significantly affect aging rate.

This study develops DNA methylation-based age estimators for deer mice using genome-wide data, showing how age, sex, genetic relatedness, and tissue type influence methylation patterns.

The paper develops DNA methylation-based age estimators for vervet monkeys and shows evolutionary conservation of epigenetic aging in primates.

The paper develops epigenetic clocks for pigs and identifies methylation differences between domestic and minipigs, linking them to obesity and aging-related genes.

The paper develops methylation-based age estimation clocks for bottlenose dolphins using blood and skin samples, achieving high accuracy with median absolute errors under 3 years.

This paper develops epigenetic clocks for rhesus macaques using methylation data from multiple tissues, showing high cross-species correlation with vervet monkeys.

This paper develops epigenetic clocks for common marmosets using DNA methylation data and tests rapamycin's effect on epigenetic age, finding no significant impact.

This paper develops epigenetic clocks for domestic cats using methylation profiles from a custom Infinium array, creating three clocks including dual-species human-cat clocks.

This study develops an epigenetic clock for sheep and finds that castration slows aging and feminizes DNA methylation at androgen-regulated loci.

This paper develops epigenetic clocks for African and Asian elephants using DNA methylation data to estimate age and identify age-related CpGs and their associated genes.

This study examines age-related DNA methylation changes in rat hippocampus and links them to spatial memory performance in young and old rats.

This paper develops epigenetic clocks for bovine oocytes and evaluates their ability to estimate chronological age and reveal differences in aging between oocytes and blood.

This paper develops epigenetic clocks for dogs to estimate age and mortality risk, and identifies methylation sites linked to breed weight and lifespan.

The paper develops epigenetic clocks and pacemaker models to predict age in plains zebras and other equids using DNA methylation data from blood samples.

This study develops DNA methylation clocks for naked mole-rats and finds that queens age more slowly than non-breeders, suggesting a link between reproductive status and epigenetic aging.

This study uses DNA methylation profiles from bats to show that age and longevity are linked to specific methylation patterns, with longevity associated with immune and cancer-related genes.

This study develops pan-primate epigenetic clocks and sex predictors using DNA methylation data from 37 primate species, achieving high accuracy for age estimation across species.

This study develops DNA methylation-based age estimators for prairie voles and finds that pair bonding slows epigenetic aging and alters methylation in brain tissue.

This study develops epigenetic clocks for rat and human tissues and shows that young plasma treatment reduces epigenetic age in multiple tissues and improves organ function.

The paper compares epigenomic and 3D genome architecture between naive and primed human embryonic stem cells, showing differences in enhancer marking and chromatin domain organization.