X. William Yang

Q-DOAS detects early protein aggregation events in real time using a proximity-quenching assay, providing quantitative data for studying neurodegenerative diseases.

The paper compares somatic CAG expansion and siRNA responses in C57BL/6 and FVB BAC-CAG HD mouse models, finding comparable expansion and MSH3-targeted siRNA efficacy.

The paper develops Perturb-CLEAR to study dendritic morphogenesis in the developing mouse cortex, revealing gene-specific multimodal phenotypes linked to NDD risk genes.

The paper uses genetic perturbations to identify modifiers of HD-associated transcriptomic networks and pathology in mice and patient-derived neurons.

The paper shows that astrocyte activity drives brainwide changes in sensory, integrative, and motor computations during a passive state in zebrafish.

This study compares striatal pathology in SCA1 and HD mice, finding shared and distinct molecular and functional deficits in Medium Spiny Neurons.

Gossamer improves neuronal reconstruction by enabling whole-brain processing with reduced memory usage and higher automated yield compared to existing methods.

The paper introduces a pipeline to profile dendritic morphology of genetically-defined single neurons in the mouse brain, revealing morphological modules and age- or HD-associated changes.

This study identifies Msh3 and Pms1 as genetic drivers of CAG-repeat migration in HD mice, leading to selective striatal and cortical pathogenesis.

This study shows that TREM2-R47H reduces amyloid plaques but fails to improve cognitive deficits or microglial reactivity in 5xFAD mice.

Recut is a framework for efficient neuronal morphology reconstruction from image volumes, achieving high throughput and memory efficiency while improving accuracy over existing methods.

This study shows that microglia and complement proteins drive early synapse loss and cognitive deficits in Huntington's disease by eliminating corticostriatal synapses, and that targeting this pathway can prevent these effects.

The paper generates a multimodal cell census and atlas of the mammalian primary motor cortex, revealing a unified molecular genetic landscape and cross-species taxonomy of cell types.

The paper maps functional domains and subnetworks in the cortico-basal ganglia-thalamic loop in mice, revealing complex patterns of convergence and divergence.

The paper provides a detailed cellular-resolution map of the mouse primary motor cortex, defining cell types and their connectivity.

This study develops an epigenetic clock for sheep and finds that castration slows aging and feminizes DNA methylation at androgen-regulated loci.

Complete morphologies of 1,708 neurons, sparsely labelled and imaged whole-brain with fMOST, expose region-specific long-range projection rules and finer diversity than current transcriptomic subtypes capture.