Innate detection of Salmonella replication triggers caspase-8-dependent apoptosis via TLR-driven TNF signaling and NLRC4-mediated sensing of the SPI-2 Type III secretion system
Beatrice I. Herrmann, Maxime Zamba‐Campero, Reyna Garcia Sillas, Winslow Yost, Lance W. Peterson, Justin L. Roncaioli, Shelley C. Rankin, Dieter M. Schifferli, Kodi S. Ravichandran, Igor E. Brodsky
The paper shows replicating Salmonella triggers TNF- and caspase-8-driven apoptosis via TLR4 and SPI-2, distinct from non-replicating Salmonella-induced pyroptosis.
bioRxiv · Sep 10, 2025 · PreprintMicrobiology