Justin L. Roncaioli

Innate detection of Salmonella replication triggers caspase-8-dependent apoptosis via TLR-driven TNF signaling and NLRC4-mediated sensing of the SPI-2 Type III secretion system

The paper shows replicating Salmonella triggers TNF- and caspase-8-driven apoptosis via TLR4 and SPI-2, distinct from non-replicating Salmonella-induced pyroptosis.

Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ

This study identifies macrophages, not neutrophils, as key in controlling Shigella through TLR-induced IL-12 and IFN-γ in a mouse model of shigellosis.