POU2AF2/OCA-T1 coactivates POU2F2 and defines a lineage-specific dependency in diffuse large B-cell lymphoma
Rima Tulaiha, Liam Shanley, Amanda Luvisotto, Ping Wang, Vipul Shukla, Zibo Zhao, Feng Yue, Ali Shilatifard, Christopher R. Vakoc, Lu Wang
This study identifies POU2AF2 as a lineage-specific dependency in DLBCL, showing it coactivates POU2F2 to sustain malignant transcriptional networks and innate-like B-cell identity.
bioRxiv · Sep 1, 2026 · PreprintCell Biology