Mtor/Rptor Function Globally Prevents Cortical Microcephaly and Cell-autonomously Promotes Postnatal Neuron Survival in Cell Type Specific Manner
Ana Villalba, Robert Beattie, Florian M. Pauler, Carmen Streicher, Osvaldo A. Miranda, Thomas Krausgruber, Martin Senekowitsch, Matthias Farlik, Christoph Bock, Thomas Ruelicke, Simon Hippenmeyer
This study investigates the role of Mtor/Rptor in cortical development, finding that its loss causes microcephaly through tissue-wide effects, while cell-autonomous Rptor function is critical for postnatal neuron survival in a cell-type-specific manner.
bioRxiv · May 5, 2026 · PreprintNeuroscience