Osvaldo A. Miranda

This study investigates the role of Pten in radial glial progenitor lineage progression and astrocyte production during cortical development, finding that Pten loss increases astrocyte generation and disrupts growth factor signaling.

This study investigates the role of Mtor/Rptor in cortical development, finding that its loss causes microcephaly through tissue-wide effects, while cell-autonomous Rptor function is critical for postnatal neuron survival in a cell-type-specific manner.

This study identifies neural oscillations and epileptiform changes in human brain organoids derived from MECP2 mutant patients using calcium imaging and extracellular recordings.

This study shows that maintaining human pluripotent stem cells with feeders improves cortical organoid formation by activating TGFβ signaling and naive pluripotency genes, which can be mimicked with TGFβ growth factors.