Carmen Streicher

Pten Orchestrates Neurogenic Radial Glia Lineage Progression and Tunes Neocortical Astrocyte Production

This study investigates the role of Pten in radial glial progenitor lineage progression and astrocyte production during cortical development, finding that Pten loss increases astrocyte generation and disrupts growth factor signaling.

Mtor/Rptor Function Globally Prevents Cortical Microcephaly and Cell-autonomously Promotes Postnatal Neuron Survival in Cell Type Specific Manner

This study investigates the role of Mtor/Rptor in cortical development, finding that its loss causes microcephaly through tissue-wide effects, while cell-autonomous Rptor function is critical for postnatal neuron survival in a cell-type-specific manner.

Lineage origin of spinal cord cell type diversity

This study traces the lineage of spinal cord progenitors in mice to show that individual progenitors can generate diverse neuron and astrocyte types, challenging the idea of fixed progenitor identities.

Early Indirect Neurogenesis transitions to late Direct Neurogenesis in mouse cerebral cortex development

The paper challenges the established model of cortical neurogenesis by showing indirect neurogenesis predominates early and shifts to direct neurogenesis later in mouse cerebral cortex development.

Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus

This study identifies multipotent progenitors in the superior colliculus that generate all excitatory and inhibitory neuron types without extrinsic input.

Tissue-wide Genetic and Cellular Landscape Shapes the Execution of Sequential PRC2 Functions in Neural Stem Cell Lineage Progression

The paper shows PRC2 has distinct, sequential functions in RGP lineage progression, acting tissue-wide for proliferation and cell-autonomously for astrocyte maturation.

Tissue-wide Effects Overrule Cell-intrinsic Gene Function in Cortical Projection Neuron Migration

This study shows that tissue-wide genetic effects override cell-intrinsic gene function in cortical neuron migration using MADM and single-cell analysis.

A Genome-wide Library of MADM Mice for Single-Cell Genetic Mosaic Analysis

The paper introduces a genome-wide MADM mouse library enabling single-cell genetic mosaic analysis and uses it to study chromosome-specific segregation biases in stem cell division.

Generation of excitatory and inhibitory neurons from common progenitors via Notch signaling in the cerebellum

The paper shows that Notch signaling regulates the fate of cerebellar progenitors to generate both excitatory and inhibitory neurons.

Heterogeneous progenitor cell behaviors underlie the assembly of neocortical cytoarchitecture

The paper quantifies progenitor cell outputs in the developing mouse neocortex, showing stochastic lineage generation of pyramidal cells leading to diverse laminar configurations.