Neuroimmune cortical organoids overexpressing C4A exhibit multiple schizophrenia endophenotypes
Morgan M. Stanton, Sara Modan, Patrick M. Taylor, Harsh N. Hariani, Jordan M. Sorokin, Brian G. Rash, Sneha B. Rao, Alejandro Tobon, Luigi Enriquez, Brenda Dang, Dorah Owango, Shannon K. O’Neill, Carlos Castrillo, Justin Nicola, Kathy Ye, , Gaia Skibinski
This study creates a C4A overexpressing neuroimmune cortical organoid model that exhibits schizophrenia endophenotypes like inflammation and synaptic pruning.
bioRxiv · Jan 20, 2023 · PreprintNeuroscience