Author

Robert P. Sosa

QB3

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:E. coli· 1 Assay:protein structure· 1

Frequent Co-Authors

Alex TongiD· 2 shared Carlos BustamanteiD· 2 shared JeongHoon KimiD· 2 shared Alfredo Jose Florez ArizaiD· 1 shared Alicia Li· 1 shared Bendix Heβ· 1 shared Christina Volz· 1 shared Daniel Pineda· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiophysics

Alex TongORCID

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2 papers

Recent·Most cited

The Central Coupler of ClpXP Controls Intersubunit Communication and Couples Intrasubunit Chemical Energy with Force Generation

Robert P. Sosa, Alfredo Jose Florez Ariza, JeongHoon Kim, Alex Tong, Zhenhui Kang, Alicia Li, John Kuriyan, Carlos Bustamante

Q208A mutations in up to four subunits of the ClpX central coupler barely slow unfolded-substrate translocation but raise ATP spent per step, weaken force generation and can abolish GFP unfolding.

bioRxiv · Oct 8, 2026 · PreprintBiophysics✦ In-depth digest

The Rossmann2x2 Fold Attains its Native Structure Via a Defined Pathway of Sequential and Cooperative Folding Units

Robert P. Sosa, JeongHoon Kim, Alex Tong, Sudeesh Krishnamurthy, Christina Volz, Bendix Heβ, Daniel Pineda, Carlos Bustamante

This study uses single-molecule force spectroscopy to show that the Rossmann2x2 fold protein folds via a defined pathway of sequential and cooperative folding units.

bioRxiv · Sep 18, 2026 · PreprintBiophysics