TRANSSULFURATION LINKS ASPARTATE-ASPARAGINE METABOLISM AND REDOX HOMEOSTASIS TO DRIVE TUMOR GROWTH
Mirko Milošević, Kristina Dmytruk, Ahmad Y. Alghadi, Pavel Jakoubě, Julian Wong Soon, Petra Hyroššová, Muhammad Bin Munim, Sara Isabel Fernandes, Anna Shevzov-Zebrun, Robert Stanko, Isidora Mitric, Zuzana Čočková, Lukáš Kučera, Juan Fernández-García, Aleš Benda, , Jakub Rohlena
This paper shows that asparagine enables transsulfuration to restore redox balance in tumors lacking aspartate synthesis enzymes, highlighting transsulfuration as a targetable vulnerability.
bioRxiv · Jul 13, 2026 · PreprintCancer Biology