Jiřı́ Neužil

This paper shows that asparagine enables transsulfuration to restore redox balance in tumors lacking aspartate synthesis enzymes, highlighting transsulfuration as a targetable vulnerability.

This study shows that α-synuclein protofibrils induce tunneling nanotubes in astrocytes, promoting stemness and apoptosis resistance through pFAK-Nanog interaction and p53 degradation.

This study shows that silencing ANT2 in P19 embryonal carcinoma stem cells reduces cell growth, promotes metabolic shifts, and increases anoikis sensitivity.

This study shows that stressed astrocytes can restore mitochondrial function through fusion with mesenchymal stromal cells, as evidenced by mitochondrial DNA transfer and long-term functional recovery.

This study examines the bioenergetic patterns of cryopreserved sperm from testicular germ cell tumor patients compared to normozoospermic samples using XF Analyzer and 2P-FLIM, revealing cryopreservation-induced metabolic impairments.

This study identifies Regeneration Initiating Cells (RICs) in Xenopus laevis tail regeneration using single cell and spatial transcriptomics, showing their role in initiating regeneration by modifying the extracellular matrix.

The paper develops a computational method to analyze mitochondrial movement in neurons and shows it detects early neurotoxicity effects from rotenone and 6-hydroxydopamine.