Muhammad Bin Munim

Physiological folate levels constrain nucleotide synthesis and increase dependence on nucleotide salvage

This study shows that physiological folate levels limit nucleotide synthesis in leukemia cells, making them reliant on salvage pathways for proliferation.

TRANSSULFURATION LINKS ASPARTATE-ASPARAGINE METABOLISM AND REDOX HOMEOSTASIS TO DRIVE TUMOR GROWTH

This paper shows that asparagine enables transsulfuration to restore redox balance in tumors lacking aspartate synthesis enzymes, highlighting transsulfuration as a targetable vulnerability.

Site of breast cancer metastasis is independent of single nutrient levels

This study shows that single nutrients do not determine breast cancer metastasis sites, and identifies purine synthesis as a key factor across multiple tissues.

Comparative analysis of plasma and bone marrow nutrient levels in pediatric B-ALL patients

This study compares nutrient levels in plasma and bone marrow of pediatric B-ALL patients, identifying metabolic differences between subtypes and highlighting unique metabolic features in B-ALL circulation.

Riboflavin drives nucleotide biosynthesis and iron-sulfur metabolism to promote acute myeloid leukemia

This study identifies riboflavin as a critical metabolic dependency in acute myeloid leukemia, showing its role in nucleotide biosynthesis and iron-sulfur cluster metabolism beyond energy production.

Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

The paper shows cancer cells adjust mitochondrial respiration to alter NAD+/NADH ratios, enhancing biomass synthesis and proliferation under nutrient limitation.