Author

Pavel Jakoubě

Czech Academy of SciencesORCID 0000-0002-5422-4136Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Ahmad Y. Alghadi· 1 shared Aleš BendaiD· 1 shared Alzbeta Baudysova· 1 shared Anna Shevzov-Zebrun· 1 shared Beata Kovarova· 1 shared Bryan P. MarzulloiD· 1 shared Chung-Weng PhangiD· 1 shared Daniel A. TennantiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Ahmad Y. Alghadi

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2 papers

Recent·Most cited

The role of autoproteolysis and mitoribosomal proteins in regulation of mitochondrial LACTB tumor suppressor

Sara Escudeiro-Lopes, Juan M. González-Morena, Alzbeta Baudysova, M. Svoboda, Pavel Marášek, Gabriel Rodríguez-Gómez, Jessica Ferreira Mendes, Chung-Weng Phang, Sravan Kumar Miryala, Pavel Jakoubě, Beata Kovarova, Susana Machado, Yuxiong Feng, Zuzana Keckesova

This study identifies a post-translational mechanism by which breast cancer cells inactivate the mitochondrial tumor suppressor LACTB through autoproteolysis mediated by MRPS34.

EMBO Reports · Sep 26, 2026Peer-reviewedCancer Biology

TRANSSULFURATION LINKS ASPARTATE-ASPARAGINE METABOLISM AND REDOX HOMEOSTASIS TO DRIVE TUMOR GROWTH

Mirko Milošević, Kristina Dmytruk, Ahmad Y. Alghadi, Pavel Jakoubě, Julian Wong Soon, Petra Hyroššová, Muhammad Bin Munim, Sara Isabel Fernandes, Anna Shevzov-Zebrun, Robert Stanko, Isidora Mitric, Zuzana Čočková, Lukáš Kučera, Juan Fernández-García, Aleš Benda, , Jakub Rohlena

This paper shows that asparagine enables transsulfuration to restore redox balance in tumors lacking aspartate synthesis enzymes, highlighting transsulfuration as a targetable vulnerability.

bioRxiv · Jul 13, 2026 · PreprintCancer Biology