Jiashu Xie

This study identifies ZW-2038, a hydroxypyridone-3-carboxamide analog, as an antiviral lead against orthopoxviruses with low micromolar potency and selectivity in human fibroblasts and organoid models.

This paper designs and synthesizes LEN analogs with improved potency against HIV-1 and resistant variants like M66I, showing significant enhancement in antiviral activity.

This study identifies two norditerpene lactones from subterranean fungi with potent anti-parasitic activity against Cryptosporidium parvum and Toxoplasma gondii, with low cytotoxicity and in vivo efficacy.

This paper develops PSA inhibitors to prolong enkephalin stability and reduce pain, showing analgesic effects in vivo and confirming their mechanism through pharmacokinetics and modeling.