Modulation of negative affective biases in male rats may predict the rapid and sustained antidepressant effects of different NMDA antagonists
Justyna K. Hinchcliffe, Katie Kamenish, Julia M. Bartlett, Roberto Arban, Bastian Hengerer, Emma S J Robinson
This study investigates how different NMDA antagonists modulate negative affective biases in rats, finding that some induce sustained positive biases linked to antidepressant effects.
bioRxiv · Feb 26, 2025 · PreprintPharmacology & Toxicology