Bastian Hengerer

Development of a genetically encoded fluorescent indicator for monitoring GPR52 activation

The paper develops a genetically encoded fluorescent sensor to monitor GPR52 activation, enabling detection of endogenous ligand release and real-time activation monitoring.

Hippocampal CA2 Inhibition Disrupts Prefrontal and Thalamic Connectivity

This study shows that inhibiting hippocampal CA2 neurons disrupts prefrontal and thalamic connectivity and impairs social behavior.

Genome-Wide Association Analysis of Tic Disorders Reveals 6 Independent Risk Loci and Highlights Tic-Associated Cell Types and Brain Circuitry

This study identifies six genome-wide significant risk loci for tic disorders and links genetic risk to specific brain cell types and circuits.

Social Context Restructures Behavioral Syntax in Mice

This study uses motion sequencing to analyze how social context affects mouse behavior, finding that a minority of behavioral units change in response to spatial proximity, not direct social contact.

Glucocorticoid receptors mediate reprogramming of astrocytes in depression.

The paper identifies glucocorticoid receptor-mediated astrocyte reprogramming in depression using post-mortem samples and mouse models.

Modulation of negative affective biases in male rats may predict the rapid and sustained antidepressant effects of different NMDA antagonists

This study investigates how different NMDA antagonists modulate negative affective biases in rats, finding that some induce sustained positive biases linked to antidepressant effects.

Influence of aversive cue detection sensitivity on extinction in adult male rats

The paper investigates how sensitivity to aversive cues affects extinction in rats, showing that low salience cues activate the BNST and that alarm call vocalizers have extinction deficits, which can be improved by glycine transmission targeting.

Reactivity to conditioned threat cues is distinct from exploratory drive in the elevated plus-maze.

This study investigates whether recall of an aversive memory affects anxiety-like behavior in the elevated plus maze, finding no significant influence and no correlation with conditioned freezing.

Functional ultrasound imaging reveals an aberrant developmental trajectory of functional connectivity in a mouse model of the 15q13.3 copy number variant microdeletion

The paper uses functional ultrasound imaging to track functional connectivity changes in a 15q13.3 microdeletion mouse model across development, identifying a critical period of network maturation linked to genotype.

Functional ultrasound imaging of recent and remote memory recall in the associative fear neural network in mice

The paper uses functional ultrasound imaging to study memory recall in mice, finding changes in neural connectivity patterns during recent and remote fear memory retrieval.

Genome-wide Association Study identifies two novel loci for Gilles de la Tourette Syndrome

This study identifies two novel genetic loci associated with Tourette Syndrome through a genome-wide meta-analysis and integrates functional data to implicate specific genes.

Impact of Fkbp5 x Early Life Adversity x Sex in Humanized Mice on Multidimensional Stress Responses and Circadian Rhythmicity

The paper investigates how FKBP5 genetic variants interact with early life adversity and sex to affect stress responses and circadian rhythms in humanized mice.

Mechanistic model-driven exometabolomic characterisation of human dopaminergic neuronal metabolism

The paper develops genome-scale metabolic models of human dopaminergic neurons to study metabolic dysfunction in Parkinson's disease using exometabolomic and transcriptomic data.

Effects of pro-depressant and immunomodulatory drugs on biases in decision-making in the rat judgement bias task

This study tests how acute and chronic pro-depressant and immunomodulatory drugs affect decision-making bias in rats using a judgement bias task, finding chronic treatments induce negative biases while acute ones do not.

Role of the medial prefrontal cortex in the effects of rapid acting antidepressants on decision-making biases in rodents

This study investigates how rapid acting antidepressants like ketamine affect decision-making biases in rodents, identifying the medial prefrontal cortex as a key region involved.