Two-color coincidence single-molecule pull-down for the specific detection of disease-associated protein aggregates
Rebecca S. Saleeb, Craig Leighton, Jieun Lee, Judi O’Shaughnessy, Kiani Jeacock, Alexandre Chappard, Robyn Cumberland, Sarah R. Ball, Margaret Sunde, David J. Clarke, Kristin Piché, Jacob Alec McPhail, Ariel Louwrier, Rachel C. Angers, Sonia Gandhi, , Mathew H. Horrocks
This paper introduces a method to specifically detect disease-associated protein aggregates using two-color coincidence single-molecule pull-down, demonstrating its effectiveness with alpha-synuclein in human biofluids.
bioRxiv · Jun 27, 2023 · PreprintNeuroscience