Margaret Sunde

A conformational switch governs the dual role of liquid-liquid phase separation in amyloid fibrillization

This study shows that the conformational state of RIPK3 RHIM domain determines whether it forms reversible condensates or amyloid fibrils, revealing a dual role for phase separation in amyloid formation.

Semaphorin 3G (SEMA3G) is a highly selective marker of cerebral amyloid angiopathy

The paper identifies SEMA3G as a specific marker for cerebral amyloid angiopathy (CAA) through analysis of human brain tissue and demonstrates its interaction with specific amyloid beta variants.

Structural Studies of an Anti-necroptosis Viral:Human Functional Hetero-amyloid M45:RIPK3 using SSNMR

This paper reports the high-resolution structure of a viral:host hetero-amyloid complex between M45 and RIPK3, revealing its mechanism of inhibiting necroptosis.

De novo Cyclic Peptides Allow Visualisation of the Monomeric and Functional Amyloid Conformations of the Kinase RIPK3

The paper identifies cyclic peptides that bind RIPK3's RHIM-containing region, enabling visualization of its monomeric and functional amyloid conformations in live cells.

iPSC-Derived PSEN2 (N141I) Astrocytes and Microglia Exhibit a Primed Inflammatory Phenotype

This study differentiates and characterizes iPSC-derived astrocytes and microglia from PSEN2 (N141I) mutation carriers, showing a primed inflammatory phenotype with altered cytokine secretion and Aβ42 handling.

Two-color coincidence single-molecule pull-down for the specific detection of disease-associated protein aggregates

This paper introduces a method to specifically detect disease-associated protein aggregates using two-color coincidence single-molecule pull-down, demonstrating its effectiveness with alpha-synuclein in human biofluids.

The RHIM within the M45 protein from murine cytomegalovirus forms heteromeric amyloid fibrils with RIPK1 and RIPK3

This study shows that the RHIM domain of M45 protein forms amyloid fibrils with RIPK1 and RIPK3, inhibiting necroptosis.